Research Article
Study of Catalytic Hydrogenation and Methanol Addition to α-Methylene-γ-Lactone of Eremanthine Derivatives
Scheme 1
Reagents and conditions: (i) H2 (50 psi), 10% Pd-C (0.1 equiv), EtOH (r. t., 5 h); (ii) H2 (40 psi), 10% Pd-C (0.1 equiv), EtOH (r. t., 3 h); (iii) H2 (30 psi), 10% Pd-C (0.1 equiv), EtOH (r. t., 1 h); (iv) H2 (5 psi), 10% Pt-C (0.1 equiv), EtOH (r. t., 30 min); (v) MeONa-MeOH (pH 11, r. t., 7 h); Substance previously described [1]; Substance previously described [2].
