Journal of Allergy

Research Article

Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data

Table 8

Epitopes associated with modulation of allergic disease.


Epitope name	Epitope sequence	Host	Response	Allergy model

Cyn d 1 (127–146)	KAGELTLQFRRVKCKYPSGT	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (19–38)	LEAKATFYGSNPRGAAPDDH	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (154–173)	KGSNDHYLALLVKYAAGDGN	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (136–155)	RRVKCKYPSGTKITFHIEKG	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (28–47)	SNPRGAAPDDHGGACGYKDV	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (82–101)	VECSGEPVLVKITDKNYEHI	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (227–246)	VIPANWKPDTVYTSKLQFGA	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (91–110)	VKITDKNYEHIAAYHFDLSG	Human	T cell, DCP	Bermuda grass pollen
Cyn d 1 (73–92)	CYEIKCKEPVECSGEPVLVK	Human	T cell, DCP	Bermuda grass pollen
Fel d 1 IPC-2	KALPVVLENARILKNCVDAKMTEEDKE	Human	T cell, LSC, NSC	Cat allergy
Fel d 1 IPC-1	KRDVDLFLTGTPDEYVEQVAQYKALPV	Human	T cell, LSC, NSC	Cat allergy
peptide 4 (P93-110)	TKCYKLEHPVTGCGERTE	Human	T cell, CLPR	Honey bee sting
peptide 1 (P81-98)	YFVGKMYFNLIDTKCYKL	Human	T cell, CLPR	Honey bee sting
Bet v 1	SKEMGETLLRAVESYLLAHSD	Mouse	B cell, AWI	Birch pollen
Der p 1 111–139	FGISNYCQIYPPNANKIREALAQPQRYCR	Mouse	T cell, DTP	European HDM
Der p 1 113–127	ISNYCQIYPPNANKI	Mouse	T cell, DTP	European HDM
Der p I (101–154)	QSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVIIGIKDLDAFRHYD	Mouse	T cell, DTP	European HDM
Der p 1 110–131	RFGISNYCQIYPPNANKIREAL	Mouse	T cell, DTP	European HDM
Der p I 114–129	SNYCQIYPPNANKIR	Mouse	B cell, DTH	European HDM
Der p 2 87–129	DIKYTWNVPKIAPKSENVVVTVKVMGDDGVLACAIATHAKIRD	Mouse	B cell, BPR, AWI	European HDM
Der p I (98–140)	AREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAV	Mouse	T cell, DTP	European HDM
Api m 4 7–19	KVLTTGLPALISW	Mouse	B cell, IgG1	Honey bee sting
Dol m 5 176–195	IEDNWYTHYLVCNYGPGGND	Mouse	B cell, IgG1	Hornet sting
Dol m 5 41–60	KNEILKRHNDFRQNVAKGLE	Mouse	T cell, DTP	Hornet sting
Dol m 5 141–160	NYKVGLQNSNFRKVGHYTQM	Mouse	T cell, DTP	Hornet sting
Cry j 2 247–258	AEVSYVHVNGAK	Mouse	B cell, CSI	Japanese cedar pollen
Cry j 2 P2 246–259	RAEVSYVHVNGAKF	Mouse	T cell, NS	Japanese cedar pollen
Ole 1 109–130	TVNGTTRTVNPLGFFKKEALPK	Mouse	B cell, AWI	Olive tree pollen
Phl p 5 peptide	YAATVATAPEVKYTVFETALKKAI	Mouse	B cell, AWI	Timothy grass pollen
Phl p 1 peptide	LRSAGELELQFRRVKCKYPEG	Mouse	B cell, AWI	Timothy grass pollen
Bet v 1/Phl p 1/Phl p 5 hybrid	MGETLLRAVESYAGELELQFRRVKCKYTVATAPEVKYTVFETALK	Mouse	B cell, AWI	Tree/Grass pollen
PI-1 IgECHε2 (109-117)	LYCFIYGHI	Mouse	T cell, PCA	Mouse
nOVA 173–196	VLVNAIVFKGLWEKAFKDEDTQAM	Rat	B cell, PCA	Chicken Egg
OVA (257–264)	SIINFEKL	Mouse	T cell, AWI	Asthma
OVA (323–339)	ISQAVHAAHAEINEAGR	Mouse	T cell, AWI	Asthma

HDM: house dust mite. Mouse strains consisted of BALB/c and C57BL/6. Rats were Norway strain. AWI: airway inflammation (histology). NS: nasal symptoms (sneezing and rubbing). CSI: cytokine suppression of allergen-IgE production. BPR: bronchopulmonary resistance. DTH: delayed type hypersensitivity. LSC: lung score. NSC: nasal score. CLPR: cutaneous late-phase reaction. DTP: decrease allergen-specific T cell proliferation. DCP: decreased allergen-specific cytokine production.