Table 2: Summary of seminal vesicle secretory proteins identified in mouse SVS.

ProteinFunctionReferenceMassWesternCancer-related studies

Upregulated expression

 Sulfhydryl oxidase 1Catalyze disulfide bond formation[25] [26, 27]
 Glia-derived nexinSerine protease inhibitor[8] [28, 29]
 Seminal vesicle secretory protein 1Amine oxidase activity/Copulatory plug formation[5]
 Seminal vesicle secretory protein 3aCopulatory plug formation[19]
 Seminal vesicle secretory protein 3βCopulatory plug formation[30]
 Seminal vesicle secretory protein 6Serine proteinase inhibitor[31] [32]

Downregulated expression

 Seminal vesicle secretory protein 2Semen-coagulating protein/Sperm decapacitation factor[6, 33] [34]
 Carcinoembryonic antigen-related cell  adhesion molecule 10Sperm binding and enhancement of sperm motility[7]
 Lysozyme C, type MPrimary bacteriolysis
 Seminal vesicle secretory protein 5Serine proteinase inhibitor[35]
 Secreted seminal-vesicle Ly-6 protein 1Potential cellular adhesion and signaling[21]
 Seminal vesicle secretory protein 7Sperm capacitation factor[20]
 Serine protease inhibitor kazal-like  proteinSerine protease inhibitor/Sperm decapacitation factor[22]
 Serine protease inhibitor Kazal-type 3Serine protease inhibitor/Sperm decapacitation factor[9]
 Seminal vesicle antigenSperm decapacitation factor[36]
 Seminal vesicle secretory protein 4Anti-inflammatory and immune-modulating agent[37]