Review Article
Can Engineered “Designer” T Cells Outsmart Chronic Hepatitis B?
Table 1
Advantages and disadvantages of CAR redirected T cell therapy.
| | Advantages | Disadvantages |
| | MHC-independent antigen targeting | empirical testing of newly generated CARs required | | High affinity binding | optimal T cell-to-target cell spacing distance required for T cell activation | | Allows production of high numbers of antigen-specific, patient-derived T cells | individual engineering of patient’s T cells necessary | | allows redirecting and T cells | short-term persistence of engineered T cells in vivo | | redirection towards a broad variety of targets possible | T cell expansion may reduce reactivity | | T cell expansion upon antigen engagement | antigen cross-reactivity increases risk of “off-target” activation and autoimmunity | | Repetitive killing possible | soluble antigen may block T cell activation |
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