International Scholarly Research Notices

Review Article

Hepatitis C Virus-Related Lymphomagenesis in a Mouse Model

Table 2

Synergistic effects of cytokines on Bcl-2 expression in WT and irf-1−/− mice in the presence of HCV core protein.
WT miceirf-1−/− mice
Mock −−
IL-2 + IL-10++++
IL-2 + IL-12+++
IL-10 + IL-12+++
IL-2−−
IL-10+++
IL-12−−
IL-2 + Il-10 + IL-12−+
Bcl-2: −, less than 2-fold increase; +, more than 2-fold increase; ++, more than 4-fold increase; +++, more than 5-fold increase (in comparison with mock treatment).