Research Article
Ferric Hydrogensulfate As a Reusable Heterogeneous Catalyst for the Synthesis of 5-Substituted-1H-Tetrazoles and Amides
Table 1
Preparation of 5-phenyl-1H-tetrazoles using varying amounts of Fe(HSO4)3 under reflux conditions.
| Entry | Solvent | Mole ratio of nitrileβ:βazide | Fe(HSO4)3 mole % | Time (h) | Yieldaβ β% |
| 1 | DMF | 1β:β1.5 | 10 | 12 | 70 | 2 | DMF | 1β:β1.5 | 10 | 18 | 96 | 3 | DMF | 1β:β1.5 | 10 | 24 | 96.5 | 4 | DMF | 1β:β1.5 | 20 | 12 | 91 | 5 | DMF | 1β:β1.5 | 5 | 12 | 49 | 6 | DMF | 1β:β1.5 | 0 | 18 | 0 | 7 | DMF | 1β:β1 | 10 | 18 | 72 | 8 | H2O | 1β:β1.5 | 10 | 24 | 20 | 9 | THF | 1β:β1.5 | 10 | 24 | 5 |
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(a) Isolated yields.
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