Research Article
Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
Table 1
Formulation and evaluation of batches in 32 full factorial design.
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*All batches contained 12.5βmilligrams of Zolpidem, 2.5βmg of talc, and 1.25βmg of magnesium stearate. indicates the ratio of HPMC K4M (%): PVP (%), and is the concentration of melt binder PEG 6000. , and indicate the percentage of drug released after 1, 4, and 8 hours, respectively. and indicate diffusion coefficient and release rate constant, respectively. |