International Scholarly Research Notices

Research Article

Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

Table 1

Formulation and evaluation of batches in 32 full factorial design.
Batch codeVariable levels in coded form 𝑄 1 𝑄 4 𝑄 8 𝑛 𝐾
𝑋 1 𝑋 2
𝐹 1 βˆ’1βˆ’181.3399.671000.0840.868
𝐹 2 βˆ’1063.9191.7698.290.1880.686
𝐹 3 βˆ’1178.7399.61000.0970.848
𝐹 4 0βˆ’174.9199.191000.1280.802
𝐹 5 0073.496.611000.1340.784
𝐹 6 0155.5888.141000.2680.603
𝐹 7 1βˆ’143.2275.2696.820.3790.44
𝐹 8 1053.3590.831000.2880.574
𝐹 9 1143.973.3293.330.3560.446
Coded valuesActual values
𝑋 1 𝑋 2
βˆ’125% : 20%15%
030% : 15%20%
135% : 10%25%
*All batches contained 12.5 milligrams of Zolpidem, 2.5 mg of talc, and 1.25 mg of magnesium stearate. 𝑋 1 indicates the ratio of HPMC K4M (%): PVP (%), and 𝑋 2 is the concentration of melt binder PEG 6000. 𝑄 1 , 𝑄 4 , and 𝑄 8 indicate the percentage of drug released after 1, 4, and 8 hours, respectively. 𝑛 and 𝐾 indicate diffusion coefficient and release rate constant, respectively.