Research Article
Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
Table 5
Kinetic treatment of dissolution data.
| | | | | | | | | | |
| | Zero order | | | | | | | | | |
| | | 1.7188 | 3.850 | 1.9727 | 2.6722 | 2.8542 | 5.42 | 7.1859 | 5.7625 | 6.6357 | | | 89.50 | 71.37 | 87.95 | 83.46 | 81.25 | 62.96 | 42.74 | 59.76 | 43.639 | | | 0.6497 | 0.8484 | 0.6567 | 0.7395 | 0.7897 | 0.8932 | 0.9799 | 0.9023 | 0.9775 |
| | First order | | | | | | | | | | | | 0.0081 | 0.0203 | 0.0095 | 0.0130 | 0.0140 | 0.0296 | 0.0449 | 0.0321 | 0.0338 | | | 1.95 | 1.8528 | 1.9418 | 1.9192 | 1.9083 | 1.8012 | 1.6650 | 1.7806 | 1.7414 | | | 0.6438 | 0.8206 | 0.6482 | 0.7276 | 0.7699 | 0.8551 | 0.9483 | 0.8664 | 0.9394 |
| | Higuchi | | | | | | | | | | | | 7.6048 | 16.077 | 8.710 | 11.572 | 69.396 | 22.35 | 28.5 | 23.64 | 26.37 | | | 81.73 | 55.93 | 79.075 | 71.90 | 12.119 | 41.81 | 16.90 | 37.51 | 19.75 | | | 0.7375 | 0.9088 | 0.7429 | 0.8216 | 0.8602 | 0.9439 | 0.9974 | 0.9497 | 0.9962 |
| | Hixon Crowell | | | | | | | | | | | | −0.028 | −0.0678 | −0.0327 | −0.044 | −0.0480 | −0.0976 | −0.141 | −0.105 | −0.131 | | | 0.1726 | 0.4946 | 0.1998 | 0.2764 | 0.3136 | 0.6578 | 1.0844 | 0.7219 | 1.069 | | | −0.645 | −0.8300 | −0.6507 | −0.7316 | −0.7765 | −0.8684 | −0.9605 | −0.8792 | −0.9594 |
| | Korsmeyer and Peppas | | | | | | | | | | | | 0.0837 | 0.187 | 0.097 | 0.128 | 0.133 | 0.267 | 0.379 | 0.288 | 0.356 | | | −0.0621 | −0.163 | −0.0711 | −0.095 | −0.105 | −0.219 | −0.355 | −0.240 | −0.350 | | | 0.8201 | 0.9435 | 0.8229 | 0.8886 | 0.9109 | 0.962 | 0.998 | 0.968 | 0.997 |
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= slope, = intercept, = square of correlation coefficient, and = diffusion exponent.
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