Chromatography Research International

Research Article

A Validated High-Performance Liquid Chromatography-Tandem Mass Spectrometric (Lc-Ms/Ms) Method for Simultaneous Determination of R(+)-Ketorolac and S(−)-Ketorolac in Human Plasma and Its Application to a Bioequivalence Study

Table 6

Pharmacokinetic parameters (mean ± SD) of ketorolac tromethamine mouth dissolving tablets (10 mg) based on its plasma concentrations.
Parameters ( 𝑛 = 2 2 )Tmax (h)Cmax (ng/ml)AUC0→t (h ng/ml)AUC0→∞ (h ng/ml)
RTRTRTRT
R(+)-Ketorolac 0 . 5 2 ± 0 . 2 7 0 . 3 7 ± 0 . 1 0 7 7 6 . 2 5 ± 2 4 5 . 5 7 8 0 8 . 5 4 ± 2 0 0 . 2 2 2 9 6 2 . 7 6 ± 8 0 0 . 1 4 3 0 4 2 . 1 0 ± 8 5 0 . 2 3 3 0 8 5 . 3 1 ± 8 2 1 . 8 3 3 1 6 3 . 3 7 ± 8 8 5 . 4 2
S(−)-Ketorolac 0 . 5 4 ± 0 . 2 6 0 . 4 1 ± 0 . 1 1 3 1 9 . 0 9 ± 1 0 7 . 7 6 3 3 8 . 5 0 ± 9 1 . 7 7 7 2 5 . 7 2 ± 2 1 5 . 9 7 7 5 5 . 0 4 ± 2 3 4 . 5 6 7 5 0 . 1 3 ± 2 1 8 . 6 7 7 7 9 . 6 7 ± 2 3 6 . 0 7
R: Reference product; T: Test product; values represented as m e a n ± S . D .