Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion
Table 2
Positive cell number of each signal (E, I) of c-ISH.
Case No.
cytology (pap)
c-ISH
L+M+S-cell
L-cell
M-cell
S-cell
E
I
pattern
E
I
pattern
E
I
E
I
1
NILM
0
0
0
0
0
0
0
0
2
NILM
0
0
0
0
0
0
0
0
3
NILM
0
0
0
0
0
0
0
0
4
LSIL
6
9
I > E #
6
9
I > E
0
0
0
0
5
LSIL
7
6
E > I #
7
6
E > I
0
0
0
0
6
LSIL
3
3
E = I #
3
3
E = I
0
0
0
0
7
LSIL
21
0
E > I #
14
0
E > I
6
0
1
0
8
LSIL
8
0
E > I #
6
0
E > I
0
0
2
0
9
LSIL
13
1
E > I #
9
1
E > I
0
0
4
0
10
LSIL
0
0
0
0
0
0
0
0
11
LSIL
1
1
E = I #
1
1
E = I
0
0
0
0
12
LSIL
9
4
E > I #
7
4
E > I
2
0
0
0
13
LSIL
5
5
E = I #
4
5
I > E
1
0
0
0
14
LSIL
2
1
E > I #
1
0
E > I
1
1
0
0
15
LSIL
0
2
I > E #
0
2
I > E
0
0
0
0
16
LSIL
0
0
0
0
0
0
0
0
17
ASC-US
1
1
E = I #
1
1
0
0
0
0
18
ASC-US
0
0
0
0
0
0
0
0
19
ASC-US
0
0
0
0
0
0
0
0
20
ASC-US
0
0
0
0
0
0
0
0
21
ASC-US
0
0
0
0
0
0
0
0
22
HSIL (moderate)
1
4
I > E #
0
3
1
1
0
0
23
HSIL (moderate)
0
0
0
0
0
0
0
0
24
HSIL (moderate)
22
35
I > E #
6
19
8
15
8
1
25
HSIL (moderate)
10
9
E > I #
0
3
0
3
10
3
26
HSIL (moderate)
13
5
E > I #
3
0
7
2
3
3
27
HSIL (moderate)
7
35
I > E #
5
11
0
13
2
11
28
HSIL (severe)
1
6
I > E #
0
1
0
1
1
4
29
HSIL (severe)
0
1
I > E #
0
0
0
0
0
1
30
HSIL (severe)
1
47
I > E #
0
0
1
10
0
37
31
HSIL (CIS)
0
1
I > E #
0
0
0
0
0
1
32
HSIL (CIS)
0
9
I > E #
0
0
0
0
0
9
33
HSIL (CIS)
2
18
I > E #
0
5
0
12
2
1
c-ISH, cytological in situ hybridization; L-cell, large-sized cell; M-cell, medium-sized cell; S-cell, small-sized cell; LSIL, low-grade intraepithelial neoplasm; ASC-US, atypical squamous cells of undetermined signification; HSIL, high-grade intraepithelial neoplasm; CIS, carcinoma in situ; E, episomal pattern; I, integrated pattern. Statistically #significant () between E ≧ I pattern in LSIL/ASC-US group and I > E pattern in HSIL group.
