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Research Article

“Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors

Table 3

Tumor growth rate (% per day) of control rats and in rats after immunization with syngeneic IFNγ secreting cells (IFNγ). Right-lateral tumors were treated with radiation therapy (RT) while left lateral tumors were not treated. The P-values of t-test versus corresponding controls are given in the right columns.


Experimental series	Treatment	TGR left 50 k cells average ± SE	N	t-test versus Ctrl	Irradiated TGR right 200 k cells average ± SE	N	T-test versus ctrl

A	Controls	10.6 ± 0.6	8		9.4 ± 1.1	8
B	Controls	8.7 ± 0.3	17		7.7 ± 0.3	17
C	Controls	9.6 ± 0.6	8		9.1 ± 0.7	8
D	Controls	7.8 ± 0.7	7		8.2 ± 0.8	7

All	Controls	9.1 ± 0.3	40		8.4 ± 0.3	40

A
B		10.0 ± 1.9	8	ns	8.5 ± 1.3	8	ns
C		8.3 ± 0.4	9	ns	6.7 ± 0.6	9	0.02
D		9.9 ± 1.4	2	ns	8.3 ± 2.4	2	ns

All		9.2 ± 0.8	19	ns	7.6 ± 0.6	19	ns

A	RT
B	RT	6.6 ± 0.6	8	0.01	4.4 ± 0.5	8	0.0001
C	RT
D	RT	5.6 ± 0.3	7	0.02	4.5 ± 0.3	7	0.002

All	RT	6.1 ± 0.4	15	<0.001	4.5 ± 0.3	15	<0.001

A	+ RT
B	+ RT	7.4 ± 1.0	8	ns	5.7 ± 0.5	8	0.006
C	+ RT
D	+ RT

All	+ RT	7.4 ± 1.0	8	ns	5.7 ± 0.5	8	<0.01