Research Article
ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy
| (a) Two-point LOD score obtained at locus D2S1782. |
| | Family ID | Expected maximum LOD score | Observed LOD score | | | | | |
| | CN | 1.84 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | I-3 | 1.94 | −2.50 | −0.32 | −0.11 | −0.03 | −0.01 | | MC | 0.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | NP | 2.55 | −3.01 | −0.53 | −0.24 | −0.10 | −0.02 | | I-4 | 1.07 | −2.13 | −0.40 | −0.14 | −0.04 | 0.00 | | DF | 0.30 | −0.19 | −0.01 | 0.03 | 0.03 | 0.01 | | CR | 0.30 | −2.41 | −0.25 | −0.09 | −0.04 | −0.02 | | CT | 0.20 | −3.13 | −1.03 | −0.61 | −0.35 | −0.15 | | FE | 0.49 | −2.51 | −0.49 | −0.27 | −0.16 | −0.08 | | PL | 0.67 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | PO | 1.28 | −2.62 | −1.05 | −0.43 | −0.15 | −0.03 | | VD | 1.84 | −0.46 | −0.28 | −0.15 | −0.07 | −0.02 | | ZN | 0.82 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | Totals | 10.75 | −18.97 | −4.37 | −2.02 | −0.91 | −0.31 |
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| (b) Two-point LOD score obtained at locus D2S369. |
| | Family ID | Expected maximum LOD score | Observed LOD score | | | | | |
| | CN | 1.84 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | I-3 | 1.94 | −2.50 | −0.32 | −0.11 | −0.03 | 0.00 | | MC | 0.37 | −2.83 | −0.44 | −0.19 | −0.08 | −0.02 | | NP | 2.55 | −3.01 | −0.53 | −0.24 | −0.10 | −0.02 | | I-4 | 1.07 | −2.30 | −0.09 | 0.03 | 0.04 | 0.01 | | DF | 0.30 | −3.19 | −0.69 | −0.32 | −0.13 | −0.03 | | CR | 0.30 | −2.69 | −0.84 | −0.51 | −0.31 | −0.14 | | CT | 0.20 | −3.25 | −1.76 | −0.95 | −0.48 | −0.18 | | FE | 0.49 | −2.36 | −0.32 | −0.12 | −0.04 | −0.01 | | PL | 0.67 | −0.15 | −0.09 | −0.05 | −0.02 | −0.01 | | PO | 1.28 | −3.42 | −1.00 | −0.45 | −0.17 | −0.04 | | VD | 1.84 | −0.46 | −0.28 | −0.15 | −0.07 | −0.02 | | ZN | 0.82 | 0.30 | 0.21 | 0.13 | 0.06 | 0.02 | | Totals | 10.75 | −25.86 | −6.16 | −2.94 | −1.31 | −0.43 |
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| (c) Two-point LOD score obtained at locus D2S2358. |
| | Family ID | Expected maximum LOD score | Observed LOD score | | | | | |
| | CN | 1.84 | −0.96 | −0.37 | −0.17 | −0.07 | −0.02 | | I-3 | 1.94 | −2.51 | −0.34 | −0.12 | −0.04 | −0.01 | | MC | 0.37 | −2.83 | −0.44 | −0.19 | −0.08 | −0.02 | | NP | 2.55 | −3.01 | −0.53 | −0.24 | −0.10 | −0.02 | | I-4 | 1.07 | −2.47 | −0.34 | −0.13 | −0.05 | −0.01 | | DF | 0.30 | −0.59 | −0.39 | −0.21 | −0.09 | −0.02 | | CR | 0.30 | −0.50 | −0.33 | −0.21 | −0.12 | −0.05 | | CT | 0.20 | −2.99 | −0.75 | −0.34 | −0.13 | −0.03 | | FE | 0.49 | 0.40 | 0.33 | 0.24 | 0.16 | 0.08 | | PL | 0.67 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | PO | 1.28 | −3.42 | −1.00 | −0.45 | −0.17 | −0.04 | | VD | 1.84 | −0.09 | −0.08 | −0.06 | −0.03 | −0.01 | | ZN | 0.82 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | | Totals | 10.75 | −18.96 | −4.23 | −1.88 | −0.70 | −0.14 |
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