Research Article

Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

Table 4

Conservation of domain fusions in Parkinson’s disease targets and human hypothetical sequences.

KEGG sequenceHypothetical protein’s Gi IDsRegion of domain fusion with the target Sequence identity in
the fused region (%)
Cd00196Cd01769Cd01809UBPARK2UBPARK2

UB591202814–82,14–82,11–82,4–72, 98
90–158,90–158,87–158,4–72,
166–234166–234163–2345–72
1205281250–10752–10750–1054–72, 30
4–72,
5–72
446628194–724–703–704–72, 30
4–72,
5–72
375891374–724–703–704–72, 30
4–72,
5–72
5799748021–8720–8717–874–72, 36
4–72,
5–72
PARK2591202814–82,14–82,11–82,4–72, 30
90–158,90–58,87–58,4–72,
166–234166–234163–2345–72
1205281250–10752–10750–1054–72, 29
4–72,
5–72
102417591–671–671–654–72, 30
4–72,
5–72