International Scholarly Research Notices

Review Article

Chronic Hypoxia Emerging as One of the Driving Forces behind Gene Expression and Prognosis of Hepatocellular Carcinoma

Table 1

List of the 7 hypoxia-related prognostic genes in HCC included in the hypoxia score. CCNG2, EGLN3, ERO1L, and WDR45L will be upregulated under hypoxia in HCC and FGF21, MAT1A, and RCL1 will be downregulated under hypoxia in HCC.
Genes in the hypoxia signature
GeneFull nameFunction or Pathway
CCNG2Cyclin G2Regulation of the cell cycle
EGLN3Egl nine homolog 1 (C. elegans)Hif1α-transcription factor network
ERO1LEndoplasmic reticulum oxidoreductin-1 LProtein processing and oxidoreductase activity
WDR45LWDR45-likeAutophagy and response to starvation
FGF21Fibroblast growth factor 21Hepatic lipid metabolism
MAT1AMethionine adenosyltransferase I alphaBiological oxidation and metabolism
RCL1RNA terminal phosphate cyclase-like 1Ribosome biogenesis