Research Article

Investigation of Archived Formalin-Fixed Paraffin-Embedded Pancreatic Tissue with Whole-Genome Gene Expression Microarray

Table 4

List of 54 significantly up- and down- regulated genes. List of significantly differentially down- and up regulated genes of insulinoma versus CHI samples. Genes are listed according to the heat map in Figure 6. Above the line are the genes downregulated in CHI samples compared to insulinoma.

SymbolGeneFunctionReference

KIAA0102 KIAA0102 gene product Development
PRY PTPN13-like, Y-linked Unknown
RASSF1 Ras association (RalGDS/AF-6) domain family 1, transcr. var. D Intracellular signaling cascade
SF3B1 Splicing factor 3b, subunit 1, 155 kDa mRNA splicing
PFKL Phosphofructokinase, liver Glycolysis[42]
TRIM15 Tripartite motif-containing 15, transcript variant 2 Mesoderm cell fate determination
CALB2 Calbindin 2, 29 kDa (calretinin), transcript variant CALB2 Calcium ion homeostasis[46]
CAPS2 Calcyphosphine 2 Intracellular signaling cascade
SUCLG2 Succinate-CoA ligase, GDP-forming, beta-subunit Glycolysis[47]
DKFZP566F0546 protein Metabolism
MYOM2 Myomesin (M-protein) 2, 165 kDa Striated muscle contraction
Similar to RIKEN cDNA 1110018M03, complete cds Mesoderm cell fate determination
APOL4 Apolipoprotein L, 4, transcript variant a Lipid transport
cDNA FLJ39458 fis, clone PROST2011297 Unknown
WIG1 P53 target zinc finger protein, transcript variant 1 RNA processing
HSPC228 Hypothetical protein HSPC228 Chemotaxis
COG7 Component of oligomeric golgi complex 7 N-linked glycosylation
mRNA for KIAA1199 protein, partial cds. N-linked glycosylation
FLII Flightless I homolog (Drosophila) Development
Human 12-lipoxygenase, partial cds. Electron transport
PFKP Phosphofructokinase, platelet Glycolysis[48]
Clone MGC: 4267 IMAGE: 3531734, complete cds. Negative regulation of transcription from polymerase II promoter
CRMP5 Collapsin response mediator protein-5; CRMP3-assoc. molec. Nitrogen metabolism
SEC8 Secretory protein SEC8 Golgi to plasma membrane transport
EML1 Echinoderm microtubule associated protein like 1 Physiological processes
FPR1 Formyl peptide receptor 1 Chemotaxis
C20orf172 Chromosome 20 open reading frame 172 Hydrogen transport
WASPIP Wiskott-Aldrich syndrome protein interacting protein Cellular morphogenesis
FLJ13868 Hypothetical protein FLJ13868 Transport
STAG3 Stromal antigen 3 Male meiosis sister chromatid cohesion

FLJ21963 Hypothetical protein FLJ21963 Metabolism
RER1 Similar to S. cerevisiae RER1 Retrograde (Golgi to ER) transport
cDNA FLJ12310 fis, clone MAMMA1001970. Unknown
HSPC182 protein, clone MGC: 2805 IMAGE: 2961422, complete cds. Amino acid metabolism
GAPDH Human glyceraldehyde-3-phosphate dehydrogenase Positive control
SLC11A3 Solute carrier family 11 (proton-coupled dival. metal ion transp.), member 3 Iron ion transport
SERPINI1 Serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 Peripheral nervous system development
AMD1 S-adenosylmethionine decarboxylase 1 Amine biosynthesis
NUCB2 Nucleobindin 2 Calcium ion homeostasis[49]
PWP1 Nuclear phosphoprotein similar to S. cerevisiae PWP1 Transcription
CCM1 Cerebral cavernous malformations 1 Small GTPase mediated signal transduction
H4FG H4 histone family, member G Nucleosome assembly
FLJ11939 Hypothetical protein FLJ11939 Neuropeptide signaling pathway
UBE2G2 Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) Physiological processes
CSN10 Casein, kappa Physiological processes
Similar to Lysophospholipase, clone IMAGE: 5589106, partial cds. Amino acid metabolism
Homo sapiens, clone IMAGE: 4330016 Unknown
TM4SF2 Transmembrane 4 superfamily member 2 Cell motility
PHC3 Polyhomeotic like 3 (Drosophila) Development
MLP MARCKS-like protein Cell motility
cDNA FLJ37605 fis, clone BRCOC2010510. Unknown
IL1A Interleukin 1, alpha Physiological processes
GORASP2 Golgi reassembly stacking protein 2, 55 kDa Intracellular signaling cascade
COX17 COX17 homolog, cytochrome c oxidase assembly protein (yeast) Copper ion transport