Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin
Table 3
Formulation and evaluation of batches in 32 full factorial design.
Batch code
Variable levels in coded form
FLT (s)
(%)
(%)
(%)
Viscosity (cps)
−1
−1
18
48.39
85.04
100.24
42.78
171.1
−1
0
15
47.41
82.82
100.37
45.51
186.3
−1
1
13
44.92
80.57
99.93
47.86
193.7
0
−1
21
44.92
80.57
99.93
48.01
211.3
0
0
15
44.21
79.16
98.80
51.11
230.4
0
1
10
41.99
77.55
98.61
54.48
356.7
1
−1
16
43.23
78.55
97.55
52.88
431.9
1
0
12
42.88
67.03
85.02
74.38
542.1
1
1
11
41.90
65.99
83.97
70.18
634.3
Coded values
Actual values
−1
2%
0.3%
0
2.5%
0.6%
1
3%
0.9%
All batches contained 7.5% of amoxicillin, 1.5% of sodium bicarbonate, 0.15% of calcium chloride, and 0.5% of sodium citrate. indicates concentration of sodium alginate, concentration of HPMC K100. , , and indicate percentage drug released after 1, 6, and 10 h, respectively. FLT indicates floating lag time; indicates similarity factor.
