Review Article
Cerebral Melanoma Metastases: A Critical Review on Diagnostic Methods and Therapeutic Options
Table 1
List of available diagnostic methods, their specific utility and Results which suggeest CNS melanoma metastasis.
| Diagnostic methods | Suggestive result | Specific utility |
| Computed tomography | Hyperdense lesion | Primary exam |
| Magnectic resonance Images | Hyperintense lesion on T1 and hypointense lesion on T2-weighted images | More detailed exam |
| Optical coherence tomography | Increased optical backscatter | Intraoperatory exam |
| Positron emission tomography | High captation of compound 18F-10B-LBPA | Noninvasive radiation dose planning |
| Cintilography | Increased uptake of iofetamine | High sensible method |
| Immunohistochemistry | Finding of intermediate filament keratin | Differentiating between metastatic melanomas and primary central nervous system tumors |
| Monoclonal antibody | Raise of fibronectin, beta 2-microglobulin | Diagnosis of metastatic meningeal melanomatosis |
| Immunocytology | IgM and IgG index, IL-6 and TNF-alpha | Diagnosis of metastatic meningeal melanomatosis |
| Transcriptase-polymerase chain reaction (PCR) | Detection of melanoma-associated markers (MAGE-3, MART-1, and tyrosinase) | Diagnosis of subclinical CNS metastases |
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