Review Article
Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia
Table 1
Overview of recent studies targeting the Wnt pathway in CLL.
| | Study | Compound | Target in Wnt pathway | Effect |
| | Lu et al. [30] | Ethacrynic acid | (i) Binding to lef-1 protein
(ii) Destabilization the lef-1/β-catenin complex | (i) Decrease of the survival of cll cells
(ii) Induction of cell death in primary cll cells |
| | Jin et al. [42] | Amides of ethacrynic acid | Modifying of sulfhydryl groups present on transcription factors in the Wnt pathway | Decrease in cll cells survival |
| | Lu et al. [43] | Salinomycin | (i) Depression of lpr6 level
(ii) Decrease of expression of Wnt target genes (lef-1, cyclin d1) | Limitation of cll cells survival |
| | Razavi et al. [44] | Nitric oxide-donating acetylsalicylic acid (no-asa) | (i) Cleavage of β-catenin
(ii) Downregulation of β-catenin/lef-1 targets | (i) Induction of apoptosis in cll cells
(ii) Tumor inhibition rate of 83.4% |
| | Gandhirajan et al. [45] | Small interfering RNA (siRNA) Cgp049090 Pkf115-584 | (i) Antagonization of lef-1
(ii) Disruption of the β-catenin/lef-1 interaction | (i) Increase of apoptosis of cll cells
(ii) Tumor inhibition of 69% and 57% |
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