International Scholarly Research Notices

Review Article

Dendritic Cell-Based Graft Tolerance

Table 1

Postulated lineageLymphoidMyeloid
DC subtypePlasmacytoid DCInterstitial DCLangerhans cell
Fully differentiated DCCD11c− CD123+CD11c+  CD123−CD11c+  CD123−
CD11b−  CD13−  CD33−CD11b+  CD13+  CD33+CD11b+  CD13+  CD33+
CD1a−CD1a−CD1a+
LocalizationT-cell zones of lymphoid organsT-cell zones of lymphoid organs immature cells in peripheral tissuesT-cell zones of lymphoid organs immature cells in epithelia
Function
 (i) Mannose receptor-mediated endocytosis—+ + +—
 (ii) IL-12+ + ++ + ++ + +
 (iii) Il-10—+ + +—
 (iv) IFNγ+ + +——
 (v) CD4+ T-cell priming+ + ++ + ++ + +