Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination
Figure 3
The influence of 61-integrin signaling on oligodendrocyte morphology. Signaling proteins FAK and Akt are phosphorylated upon LN2-mediated activation of α6β1-integrin. Similarly, Fyn is activated via α6β1-integrin binding to LN2, thereby activating the cytoskeletal remodeling proteins Rho, Cdc42, and Rac1. The activation of FAK, Akt, Rho, Cdc42, and Rac1 by α6β1-integrin signaling impacts on oligodendrocyte process extension and is likely implicated in oligodendrocyte development. Solid and dashed lines, respectively, represent direct and indirect interactions.
