Inability to image lesions with heavy calcium burden, IV contrast, radiation exposure
Cardiac MRI
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Acquisition time, unstable patients, metallic fragments
Positron emission tomography
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Limited spatial resolution, ionizing radiation, requires coregistration with CT or MRI, hindered by cardiac and respiratory motion
Single photon emission tomography
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longer imaging protocols for stress rest comparison, radiation exposure, lower spatial resolution than echocardiography underestimate three vessel CAD due to balanced ischemia, attenuation artifacts
IVUS/OCT
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Time consuming each coronary artery must be imaged separately, limited spatial resolution of >100 μm with IVUS, limited depth penetration with OCT