Organic Chemistry International
Volume 2011 (2011), Article ID 360810, 5 pages
Research Article

Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1,3-diones

1Post Graduate and Research Department of Chemistry, Sri Paramakalyani College, Alwarkurichi, Tirunelveli 627 412, India
2Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India

Received 7 April 2011; Accepted 7 June 2011

Academic Editor: William Ogilvie

Copyright © 2011 Malaichamy Jeyachandran and Penugonda Ramesh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2-(Arylsulfonyl)indane-1,3-diones, earlier synthesized by Claisen condensation involving diethyl phthalate and aryl methyl sulphones, are found to be potent blood anticoagulants. In search of improved analogs of 2-(arylsulfonyl)indane-1,3-dione, we have synthesized them (7 a-f) by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates in the presence of pyridine-piperidine medium for the first time. The synthesized 2-(arylsulfonyl)indane-1,3-diones were evaluated for antimicrobial and anticoagulant activities and all of them registered significant activity.