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Penicillins |
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Reference | Year | Country | No. | Exposure | Latency | Respiratory symptoms | Skin test | Specific IgE | Bronchial provocation test | Oral challenge |
|
[7] | 1953 | USA | 2 | penicillin | #1: “weeks” #2: 1 year | #1: cough, rhinitis #2: cough, rhinitis, wheeze | Procaine penicillin (+) | not reported | not reported | not reported |
[8] | 1957 | France | 4 | penicillin | #1: “years” #2: 3 months #3: 1 year #4: 1 year | #1: cough, rhinitis, dyspnoea #2: dyspnoea, eczema #3: dyspnoea #4: asthma, dyspnoea, eczema | not reported | not reported | not reported | not reported |
[9] | 1960 | France | 2 | penicillin | #1: 1 year #2: 7 years | #1: asthma, urticaria #2: asthma | #1: PMP* (+) #2: penicillin (+) | not reported | not reported | not reported |
[10] | 1974 | UK | 3 | ampicillin BP* 6 APA* | #1: 2 years #2: 2 years #3: 2 years
| asthma () rhinitis () eczema () conjunctivitis () | ampicillin (−) ampicillin polymer (−) BPP* (−) MDM* (−) | not reported | #1: ampicillin (+LR*)6APA* (+/−) #2: ampicillin (+LR*) BP*(+LR*) commercial 6APA* (+LR*) purified 6APA* (−) BPP* (−) #3: ampicillin (+LR*) BP* (+LR*) 6APA* (−) | #1: ampicillin (−) #2: ampicillin (+LR*) and intestinal symptoms #3: BP* (+ER*) and urticaria |
[11] | 1980 | Spain | 2 | amoxicillin ampicillin | #1: 1 year #2: 1 year
| #1: rhinitis, dyspnoea, wheeze #2: cough, wheeze | not reported | negative | not reported | not reported |
[12] | 1982 | Germany | 1 | ampicillin | NS* | cough, rhinitis, dyspnoea, fever | ampicillin (−) | BPP* (+) | antibiotic mix (+LR*) | not reported |
[13] ne | 1997 | Belgium | 1 | amoxicillin | 6 months | cough, wheeze, rhinitis | not reported | not reported | amoxicillin (+ER* LR*) | not reported |
[14] | 1998 | Spain | 1 | amoxicillin | 27 years | cough, rhinitis, wheeze, dyspnoea | amoxicillin (−) ampicillin (−) BP* (−) BPP* (−) MDM* (−)
| amoxicillin (+) ampicillin (−) (penicillin V (−) | amoxicillin: (+ER*) penicillin V (−) | amoxicillin (+LR*) penicillin V (−) |
|
Cephalosporins |
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Reference | Year | Country | No. | Exposure | Latency | Allergic symptoms | Skin test | Specific IgE | Bronchial provocation test | Oral challenge |
|
[11] | 1980 | Spain | 1 | cephalexin, | 3 months | cough, wheeze | PP* (−) penicillin G (−) | negative | not reported | cephalosporin (NS) (+) and rhinitis, urticaria |
[15] | 1981 | UK | 2 | 7ACA* 7CTD* | #1: NS* #2: 10 years | #1: cough, rhinitis, chest tightness #2: chest tightness, dyspnoea | #1: 7ACA (+) 7CTD (+) cefalexin (−) #2: cephalexin (+) | not reported | #1: 7ACA (+ER*) 7CTD (+ER*) cephalexin (−) #2: cephalexin (+ER*) | not reported |
[16] | 1995 | UK | 1 | ceftazidime | 1 year | rhinitis, dyspnoea | not reported | not reported | ceftazidime (+ER* LR*) | not reported |
[17] | 1996 | Italy | 1 | cefmetazole 7-ACA* | 1 year | cough, rhinitis, bronchospasm | cefmetazole (−) 7-ACA* (−) | penicillin G (−) penicillin V (−) | cefmetazole (+NS*) 7-ACA (+NS*) | not reported |
[18] | 1999 | Spain | 1 | cefadroxil | 9 months | cough, rhinitis, dyspnoea, chest tightness | PP* (−) MDM* (−) BP* (−) amoxicillin (−) cefadroxil (−) | penicillin G (−) penicillin V (−) amoxicillin (−) ampicillin (−) cefaclor (−) | cefadroxil (+ER*) | amoxicillin (−) cephalexin (+ER*) |
[19] | 2003 | Korea | 2 | cefteram | NS* | NS* | #1: cefteram (+) #2: cefteram (+) | #1: cefteram-HSA* (+) #2: cefteram-HSA* (+) | #1: cefteram (+ER*) #2: cefteram (+ER*) | not reported |
[20] | 2004 | Korea | 2 | 7-ACA* ceftriaxone | 2 years | #1: rhinitis, respiratory symptoms #2: rhinitis, respiratory symptoms | #1: 7-ACA* (+) ceftriaxone (+) #2: 7-ACA* (−) ceftriaxone (−)
| #1: 7-ACA-HSA* (+) #2: 7-ACA-HAS* (−) | #1: 7-ACA* (+ER*) ceftriaxone (−) #2: 7-ACA* (+NS*) ceftriaxone (−) | not reported |
[21] | 2009 | Italy | 1 | 7-TACA* Cephalosporins | 8 months | cough, rhinitis, dyspnoea | not reported | not reported | 7-TACA*: (+ER*) | not reported |
|
Miscellaneous |
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Reference | Year | Country | No. | Exposure | Latency | Allergic symptoms | Skin test | Specific IgE | Bronchial provocation test | Oral challenge |
|
[22] | 1977 | India | 1 | tetracycline | 1 year | cough, wheeze, dyspnoea | not reported | not reported | tetracycline (+ER*) | tetracycline (+ER*) and urticaria |
[23] | 1975 | UK | 1 | spiramycin | 1 year | cough, rhinitis, dyspnoea, dermatitis | spiramycin (+) | not reported | spiramycin (+LR*) | not reported |
[24] | 1979 | Italy | 1 | spiramycin | 1 year | cough, asthma, dermatitis | spiramycin (+) | not reported | chick feed with spiramycin (+LR*) | not reported |
[25] | 1984 | Italy | 2 | spiramycin adipid acid | #1:14 years #2:7 months | #1: dyspnoea #2: cough, dyspnoea | not reported | not reported | #1: spiramycin adipate (+ER* LR*) #2: spiramycin adipate (+ER*) spiramycin base (+ER* LR*) | not reported |
[26] | 1995 | Italy | 1 | piperacillin | 22 months | rhinitis, dyspnoea, wheeze, rash | piperacillin (+) | not reported | piperacillin (+ER*) | not reported |
[27] | 2006 | Korea | 2 | thiamphenicol | NS* | #1: rhinitis, asthma #2: rhinitis, asthma | #1: thiamphenicol (+) #2: thiamphenicol (+) | #1: thiamphenicol (+) #2 thiamphenicol (+) | #1: thiamphenicol (+ER*) #2: thiamphenicol (+ER*) | not reported |
[28] | 2009 | Korea | 1 | vancomycin | 5 months | rhinitis, chest tightness | vancomycin (−) | vancomycin-HSA* (−) | not reported | not reported |
[29] | 2010 | Spain | 1 | colomycin | 3 months | rhinitis, cough, wheeze, dyspnoea | not reported | negative | colomycin (+ER*) | not reported |
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