Th2 Cytokine Levels Distort the Association of IL-10 and IFN- with Allergic Phenotypes
Table 6
Odds ratios of IL-10 and IFN- for atopy estimated by two adjusted methods*.
Method one
Method two
OR
95% CI
OR
95% CI
P
Lower
Upper
Lower
Upper
IL-10 stimulated with HDM (HDM)
Raw
.762
.544
1.066
0.11
By IL-5
.481
.307
.755
0.001
.567
.390
.825
0.003
By IL-13
.602
.402
.902
0.014
.614
.415
.909
0.015
By IL-9
.628
.427
.924
0.018
.631
.430
.926
0.019
By IL-4
.693
.484
.992
0.045
.693
.485
.992
0.045
IL-10 (PHA)
Raw
.615
.392
.963
0.034
By IL-5
.401
.226
.712
0.002
.403
.227
.715
0.002
By IL-13
.472
.278
.802
0.005
.489
.293
.817
0.006
IL-10 (SEB)
Raw
.607
.357
1.031
0.065
By IL-5
.416
.224
.770
0.005
.427
.232
.784
0.006
By IL-13
.480
.259
.890
0.020
.489
.267
.894
0.020
IFN- (HDM)
Raw
.838
.673
1.043
0.114
By IL-5
.635
.473
.853
0.003
.720
.567
.914
0.007
By IL-13
.670
.503
.893
0.006
.681
.515
.900
0.007
By IL-9
.769
.599
.987
0.039
.772
.603
.988
0.040
By IL-4
.822
.655
1.033
0.092
.822
.655
1.033
0.093
IFN- (PHA)
Raw
.645
.433
.963
0.032
By IL-5
.437
.260
.734
0.002
.433
.256
.732
0.002
By IL-13
.502
.311
.812
0.005
.517
.323
.827
0.006
IFN- (SEB)
Raw
.836
.500
1.399
0.50
By IL-5
.788
.467
1.330
0.37
.794
.472
1.337
0.39
By IL-13
.815
.485
1.368
0.44
.815
.484
1.370
0.44
*Method one: “Raw” model only includes one independent variable: either raw IL-10 or IFN-; “by IL-5” includes either raw IL-10 or IFN- and IL-5; “by IL-13” includes either raw IL-10 or IFN- and IL-13; “by IL-9” includes either raw IL-10 or IFN- and IL-9; “by IL-4” includes either raw IL-10 or IFN- and IL-4. Method two: either adjusted IL-10 or IFN- was fitted in the logistic regression model.; “by IL-5”, “by IL-13”, “by IL-9”, and “by IL-4”indicate that the levels of either adjusted IL-10 or IFN- was adjusted by IL-5, IL-13, IL-9, and IL-4, respectively.
