Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged

<table>Vascular compartmentalization of angio-gene expression in a large tumor. Tumor vasculature was laser microdissected and its gene expression profile was compared to that of the tumor as a whole. Values represent mRNA levels adjusted to GAPDH. Mean values ± SD of 3 qPCR analyses, except for CD31, VE-cadherin, vWF, EphrinB2, EphB4, Integrin <i>α</i>v, VEGFR2, Tie2, iNOS, eNOS, TNF<i>α</i>, TNFR1, TNFR2 (a total of 5 qPCR analyses), and for VEGF (a total of 7 qPCR analyses) and PCNA (qPCR in quadruplicate). *<svg height="11.25" id="M8" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</svg>. ND: not detectable.</table>

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Figure 4

Figure 4: Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged 

Figure 4 | Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged 