Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged

<table>Vessels with different morphological appearance are covered with pericytes presenting with a different pattern of pericyte marker expression. (a, b) Immunofluorescent double staining for CD31 (green) and desmin (red) or <i>α</i>-SMA (red) and nuclear counter stain (DAPI; blue) of a representative tumor from the group of late-stage, large volume tumors (Magnification 200x). (c) Immunohistochemical detection of Ki67 revealed homogeneous distribution of proliferative activity throughout the whole tumor, in all three stages of tumor growth (Magnification 200x). Arrows point to Ki67-positive endothelial nuclei.</table>

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Figure 6

Figure 6: Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged 

Figure 6 | Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged 