International Journal of Proteomics

Review Article

The Use of Protein-Based Biomarkers for the Diagnosis of Cystic Tumors of the Pancreas

Table 2

Potential biomarkers identified to date in pancreatic cyst fluid.
Genetic biomarkersReferences
DNA-based
 K-ras [49]
 Allelic loss amplitude [49]
RNA-based
 miR-21[60]
 miR-155[60]
Protein-based biomarkers
 Prostaglandin E(2)[63]
 Interleukin-1 [69]
 MUC1 [81, 82]
 MUC2 [66]
 MUC4 [66]
 MUC5AC [81–83]
 MUC5B [81]
 MUC6 [81, 83]
 MUC16 [81]
 MUC18[83]
 CA 19-9 [82]
 Plectin-1[68]
 S100-A6, 8, 9, 11 [81]
 CEACAM 1, 5, 6, 7 [81]
 BGP-1[83]
 Tspan-8, 27, 28[83]
 CD55[83]
 E-cad[83]
 Glutathione S-transferase P[83]
 Olfactomedin-4[83]
 Prostate stem cell antigen[83]
 Pyruvate kinase isozymes M1/M2[83]
 Ras-related protein Rab-8A[83]
 Rho-related GTP-binding protein RhoC[83]
 Trefoil factor 1,2[83]
 VE-cadherin[83]
 Protein-Z-dependent protease inhibitor[83]
 von Willebrand antigen 2[83]