Review Article
Immunopathogenesis in Chlamydia trachomatis Infected Women
Table 2
Host factors and cellular immune responses associated with susceptibility or protection from infection and/or diseases.
| | Host factor or response | Association | References |
| | IFN-γ production by PBMCs stimulated with Ct-hsp60 | Protection from incident C. trachomatis infection | [34] | | Low PBMC IFN-γ and high IL-10 responses to Ct-hsp60 | Increased risk of C. trachomatis infection and PID | [7] | | Low CD4 cell count in HIV-infected women | Increased risk of PID | [35] | | Neutrophils and neutrophil defensin levels in cervical secretions | Positive correlation with histologic endometritis in girls with clinical PID | [36] | | IL-10 promoter polymorphism (IL-10-1082AA); IL-2 reduction | Increased risk of infertility | [37] | | Cervical cell production of IL-1β, IL-6, IL-8, and IL-10 in response to stimulation with Chlamydia trachomatis EBs | Positive correlation with infertility in C. trachomatis-seropositive patients | [11] | | Cervical cell production of IFN-γ and IL-12 in response to stimulation with Chlamydia trachomatis EBs | Positive correlation with fertility in C. trachomatis-seropositive patients | [1] |
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Legenda: Ct-hsp60: Chlamydia trachomatis heat-shock protein 60; EBs: elementary bodies; IFN: interferon; PID: pelvic inflammatory disease; PBMCs: peripheral blood mononuclear cells.
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