Review Article
Isolation and Identification of Candida from the Oral Cavity
Table 2
Virulence factors associated with Candida Albicans.
| Virulence factor | Effect |
| Adherence | Promotes retention in the mouth | Relative cell surface hydrophobicity | Nonspecific adherence process | Expression of cell surface adhesion molecules | Facilitates specific adherence mechanisms | Evasion of host defenses | Promotes retention in the mouth | High frequency phenotypic switching | Antigenic modification through frequent cell surface changes | Hyphal development | Reduces likelihood of phagocytosis; allows phagocytosed yeast to escape phagocyte | Secreted aspartyl proteinase production | Secretary IgA destruction | Binding of complement molecules | Antigenic masking | Invasion and destruction of host tissue | Enhances pathogenicity | Hyphal development | Promotes invasion of oral epithelium | Secreted aspartyl proteinase production | Host cell and extracellular matrix damage | Phospholipase production | Damage to host cells |
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