International Scholarly Research Notices

Review Article

Isolation and Identification of Candida from the Oral Cavity

Table 2

Virulence factors associated with Candida Albicans.
Virulence factorEffect
AdherencePromotes retention in the mouth
Relative cell surface hydrophobicityNonspecific adherence process
Expression of cell surface adhesion moleculesFacilitates specific adherence mechanisms
Evasion of host defensesPromotes retention in the mouth
High frequency phenotypic switchingAntigenic modification through frequent cell surface changes
Hyphal developmentReduces likelihood of phagocytosis; allows phagocytosed yeast to escape phagocyte
Secreted aspartyl proteinase productionSecretary IgA destruction
Binding of complement moleculesAntigenic masking
Invasion and destruction of host tissueEnhances pathogenicity
Hyphal developmentPromotes invasion of oral epithelium
Secreted aspartyl proteinase productionHost cell and extracellular matrix damage
Phospholipase productionDamage to host cells