Research Article
Development of Topical Niosomal Gel of Benzoyl Peroxide
Table 4
Table reflects data of optimization of speed of rotation, intensity of vacuum, temperature, and annealing time.
| | Formulation code | Speed of rotation (rpm) | Intensity of vacuum (mmHg) | Temperature
(°C) | Annealing time (Hour) | Percentage drug Entrapments ± %SD | Average particle size ± %SD |
| | NF21 | 50 (−1) | 20 (−1) | 60 (−1) | 1 (−1) | 92.16% (±2.43) | 4.78 (±0.09) | | NF22 | 75 (+1) | 25 (+1) | 60 (−1) | 1 (−1) | 79.67% (±1.27) | 6.67 (±0.22) | | NF23 | 75 (+1) | 20 (−1) | 70 (+1) | 1 (−1) | 80.11% (±3.31) | 7.81 (±0.32) | | NF24 | 75 (+1) | 20 (−1) | 60 (−1) | 2 (+1) | 89.55% (±3.90) | 2.43 (±0.03) | | NF25 | 50 (−1) | 25 (+1) | 70 (+1) | 1 (−1) | 77.34% (±2.88) | 5.66 (±0.11) | | NF26 | 50 (−1) | 25 (+1) | 60 (−1) | 2 (+1) | 81.14% (±2.11) | 5.22 (±0.14) | | NF27 | 70 (−1) | 20 (−1) | 70 (+1) | 2 (+1) | 80.12% (±3.78) | 4.06 (±0.16) | | NF28 | 75 (+1) | 25 (+1) | 70 (+1) | 2 (+1) | 75.54% (±2.21) | 4.43 (±0.13) |
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; batch NF21 was taken and optimized for the abovementioned variables.
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