Research Article
Development of Topical Niosomal Gel of Benzoyl Peroxide
Table 6
Table contains data of drug leakage study at RT and refrigerated temperature.
| | Time in weeks | Percentage drug retained (±SD) | | Niosomal suspension | Niosomal gel of Carbopol | | 4°C (NS) | RT (NS) | 4°C (NG) | RT (NG) |
| | 1 | 98.90 (±3.74) | 89.11 (±3.33) | 99.89 (±3.26) | 94.20 (±2.72) | | 2 | 97.30 (±3.67) | 78.83 (±3.41) | 99.22 (±2.11) | 87.09 (±3.92) | | 3 | 95.89 (±3.16) | 68.22 (±2.98) | 98.73 (±3.94) | 81.82 (±3.16) | | 4 | 93.55 (±2.71) | 61.19 (±2.86) | 98.32 (±4.02) | 76.90 (±3.57) | | 5 | 89.48 (±1.76) | 54.40 (±1.99) | 98.02 (±3.65) | 72.10 (±1.78) | | 6 | 86.88 (±1.24) | 46.21 (±1.32) | 97.77 (±2.83) | 68.89 (±2.78) | | 7 | 82.77 (±2.43) | 39.11 (±0.74) | 97.56 (±1.98) | 65.11 (±2.67) | | 8 | 78.92 (±0.74) | 33.38 (±0.43) | 97.38 (±2.87) | 61.08 (±1.96) | | 9 | 75.45 (±1.17) | 28.39 (±1.15) | 97.22 (±3.49) | 58.12 (±1.14) | | 10 | 73.29 (±1.87) | 23.45 (±1.07) | 97.07 (±2.67) | 56.23 (±1.08) | | 11 | 70.67 (±2.87) | 20.04 (±0.56) | 96.97 (±1.10) | 53.55 (±1.17) | | 12 | 65.89 (±1.65) | 17.12 (±0.48) | 96.85 (±2.26) | 51.07 (±2.22) |
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; RT: room temperature (25 ± 2°C); NS: niosomal suspension; NG: niosomal gel.
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