Synthesis of β-Amino Carbonyl Compounds via the Iodine-Alumina Catalyzed Three-Component Coupling Reaction under Microwave Irradiation

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr class="thead"><td align="left">Substrate 1 R1</td><td align="center">Substrate 2 R2</td><td align="center">Substrate 3 R5</td><td align="center">I2-Al2O3 (mol %)</td><td align="center">Time (min)</td><td align="center">Product 4</td><td align="center">Yielda/(%)</td></tr><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td align="left">4-ClC6H4</td><td align="center">C6H5</td><td align="center">3-ClC6H4</td><td align="center">10</td><td align="center">12</td><td align="center">4a</td><td align="center">57</td></tr><tr><td align="left">4-ClC6H4</td><td align="center">C6H5</td><td align="center">3-ClC6H4</td><td align="center">20</td><td align="center">12</td><td align="center">4a</td><td align="center">92</td></tr><tr><td align="left">4-ClC6H4</td><td align="center">C6H5</td><td align="center">3-ClC6H4</td><td align="center">20</td><td align="center">20</td><td align="center">4a</td><td align="center">90</td></tr><tr><td align="left">4-ClC6H4</td><td align="center">C6H5</td><td align="center">3-ClC6H4</td><td align="center">40</td><td align="center">12</td><td align="center">4a</td><td align="center">91</td></tr><tr class="table-tr"><td colspan="7"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>
								aIsolated yields. </td></tr></table>

Optimization of the amount of I2-Al2O3 catalyst.

Organic Chemistry International

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Table 1

Table 1: Synthesis of β-Amino Carbonyl Compounds via the Iodine-Alumina Catalyzed Three-Component Coupling Reaction under Microwave Irradiation