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Research Article

Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro

Table 1

IC25 and IC50 values for the effects of urea, creatinine, and iron on respiratory burst of nonprimed and LPS-primed peritoneal phagocytes.
Tested agentUsed phagocytesIC25IC50
UreaNonprimed18.3 mM(17.3–19.5)>50 mM—
LPS-Primed6.1 mM(5.3–6.9)>50 mM—
CreatinineNonprimed973.3 μM(940.1–1007.6)>1000 μM—
LPS-Primed455.3 μM(444.9–465.8)>1000 μM—
Iron ions Fe3+Nonprimed9.5 mM(5.3–10.0)34.5 mM(32.8–36.2)
LPS-Primed7.3 mM(4.7–8.3)26.8 mM(26.2–27.5)
Numbers in parentheses indicate interpolated values for IC25 or IC50 ± SEM (based on AUC values from five independent experiments).