Responses after randomization; (a) albumin : creatinine ratio; (b) visit systolic BP; (c) visit diastolic BP; (d) HbA1c level; (e) estimated glomerular filtration rate; (f) right CIMT; (g) left CIMT; (h) reactive hyperemia-induced peripheral arterial tonometry; (i) nitroglycerine-induced peripheral arterial tonometry; (j) highly sensitive C-reactive protein. The number of subjects followed at each three month interval in the aggressive- and low-dose groups, respectively, were three months-11 and 12; six months-9 and 11, nine months-8 and 9, 12 months 6 and 6; 15 months-6 and 6; and 18 months-5 and 5. Standard : low dose. Data in graphs (a), (b), (c), and (e) were measured monthly but shown bimonthly for ease of presentation.