Synthesis and In Vitro Evaluation of Novel Nortropane Derivatives as Potential Radiotracers for Muscarinic M2 Receptors

<table>Reagents and conditions: (i) NH2NH2, NaOH; (ii) Ac2O, pyridine; (iii) 4-Iodobenzyl bromide, DMF; (iv) 4-Iodobenzoyl chloride, DMAP, Et3N, CH2Cl2; (v) α-chloroethyl chloroformate, Toluene; (vi) MeOH; (vii) TBDMSCl, DMAP, Et3N, DMF; (viii) Mg, 1,4-dibromobenzene, THF; (ix) HCl (2 M), THF, EtOH (1/1/1); (x) Ac2O, pyridine; (xi) H2, Pd/C. Variants 4a–c: R (a) CH3CO, (b) p-IPhCH2, and (c) p-IPhCO.</table>

International Journal of Molecular Imaging

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Figure 1

Figure 1: Synthesis and In Vitro Evaluation of Novel Nortropane Derivatives as Potential Radiotracers for Muscarinic M2 Receptors