The use of ACD histograms in the analysis of cerebral malignancies. (a) Total enhancing tumor volume was segmented on axial postcontrast T1-weighted images in a 52-year-old woman with recurrent GBM and transferred to (b) the corresponding ADC map image for generation of ADC histogram (c, d). (c) A single distribution-fitted curve provided a poor fit of the data, which could be substantially improved by using (d) a two-component normal mixture model (From [33]) Reprinted with permission.