Clinical Study
Comparison between Airway Responses to High versus Low Molecular Weight Compounds in Occupational Asthma
Table 1
Characteristics of the compounds used for performing specific inhalation tests (SIC), concentrations used during SIC and duration of the exposure.
| Agent | Control | Number of subjects | Challenge concentration | Time exposure |
| TDI vapours | Diluent | 37 | 0.002–0.003 ppm | 30–120′ | Flour dust | Lactose dust | 20 | 0.3–0.5 mg/m3 | 30′ | Wood dusts | Lactose dust | 3 | 0.3–0.5 mg/m3 | 30′ | Persulfate salts | Lactose dust | 6 | 0.05–0.1 mg/m3 | 30′ | Aziridine | Lactose dust | 2 | 0.03–0.05 mg/m3 | 30′ | Latex solution | Normal saline | 3 | <0.0001 mg/m3 | 30′ | Tobacco dusts | Lactose dust | 1 | 0.3–0.5 mg/m3 | 30′ | Phenolic resins and Detergents vapours | Diluent | 2 | Not measured* | 30′ |
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*Subjects simulated the job activity in laboratory.
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