Research Article
2-Pyrrolidinones and 3-Pyrrolin-2-ones: A Study on the Chemical Reactivity of These Structural Moieties
Scheme 1
Reagents and conditions: (a) (i) NaH (1.2 equiv), THF (r.t., 15 min), (ii) (Boc)2O (1.2 equiv, r.t., 40 min); (b) (i) LDA (1.4 equiv, −78°C, 30 min), (ii) (PhS)2 (1.4 equiv), THF [−78°C (15 min), r.t. (2 h)]; (c) (i) Et3N (5.0 equiv), TMSCl (3.0 equiv), CH2Cl2 (−15°C, 10 min), (ii) I2 (2.0 equiv, 0°C, 2 h).
