The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-β Signaling in Breast Cancer Malignancy
Figure 2
Alk5TD signature is associated with clinical outcome in women with breast cancer (figure adapted from [27]). (a) Hierarchical clustering of 295 breast tumors [28, 29] using 90 overlapping genes with the 271-gene Alk5TD signature. (b) Kaplan Meier plots for recurrence-free survival (RFS) and overall survival (OS) comparing the two groups of tumors with and without a correlation with the Alk5TD signature. (c) Hierarchical clustering of 22 breast tumors from patients who were treated with navelbine and trastuzumab [30] using 190 overlapping genes with the 271-gene Alk5TD signature. Cluster 2 shows a positive correlation with the Alk5TD signature. (d) Box-and-Whisker plot of standard pearson correlation between the Alk5TD signature and clusters determined in (c).
