Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety
Table 3
Changes in cytokine production at day 7 allergen-specific stimulation: baseline versus postbaseline.
Variable
Citrus/Cydonia comp.
Gencydo
Baseline (PPS/OC)
Postbaseline (PPS/OC)
Change (PPS/OC)(95% CI)
Baseline
Postbaseline
Change (95% CI)
IL-10#
2.36/2.37
1.68/1.70
−0.68*(−0.37 to −1.00)/−0.67*
2.22
1.79
−0.44*(−0.19 to −0.68)
IL-12
0.15/0.16
0.26/0.29
0.11/0.13
0.27
0.25
−0.02
IFN-γ
3.01/3.1
2.7/2.8
−0.31/−0.3
3.14
3.17
0.03
IL-5
2.21/2.27
2.06/2.05
−0.15/−0.22
2.29
2.3
0.01
IL-13
2.28/2.4
2.22/2.22
−0.06/−0.18
2.40
2.43
0.03
#All cytokine scores (IL-10, IL-12, IFN-γ, IL-5, and IL-13) are log10 transformed scores. PPS = Per Protocol Set. OC = Observed Cases.
*
, **, ***.
