Journals
Publish with us
Publishing partnerships
About us
Blog
Journal of Allergy
Table of Contents
Special Issues
Journal of Allergy
/
2011
/
Article
/
Tab 1
/
Review Article
Haptenation: Chemical Reactivity and Protein Binding
Table 1
Common mechanistic domains.
Mechanistic domain
Michael acceptors
Acylating agents
Schiff base formers
S
N
Ar electrophiles
S
N
1/S
N
2 electrophile
X = electron withdrawing
X = electron withdrawing and a good leaving group.
Attacking nucleophile is an amine (NH
2
-)
X = usually a halogen or pseudohalogen.
Y
1
,Y
2
= electron withdrawing
X = usually electron withdrawing and a good leaving group.