Review Article
Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding
Table 1
Mutations in the conserved ATP binding/hydrolysis domain and phenotypes in GroEL and three subunits of CCT complex.
| Subunit | Amino acid replacement | Phenotype | References |
| GroEL | G35E | Normal | [96] | GroEL | D87N | Lethal | [96] | GroEL | D87K | Lethal | [96] | Cct1p | G45S | CS | [93] | Cct1p | G48E | HS | [92] | Cct1p | D96E | CS | [93] | Cct1p | G423D | HS | [93] | Cct2p | G41E | Lethal | [94] | Cct6p | G38S | Normal | [95] | Cct6p | G41E | TBZS, NaClS | [95] | Cct6p | G59R | TBZSS, NaClS | [95] | Cct6p | D89E | TBZS | [95] | Cct6p | G90E | TBZSS, NaClS | [95] | Cct6p | G414E | CS | [95] | Cct6p | G416D | Normal | [95] | Cct6p | G416E | CS | [95] |
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CS: Cold sensitive; HS: heat sensitive; TBZS: Thiabendazole sensitive; TBZSS: Thiabendazole-hyper sensitive; NaClS: Sodium chloride sensitive.
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