Downregulation of the Adenosine A2b Receptor by RNA Interference Inhibits Hepatocellular Carcinoma Cell Growth

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Group</td><td align="left"><i>N</i></td><td align="left">G0/G1 (%)</td><td align="left">S (%)</td><td align="left">G2/M (%)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">pSilencer3.1-neo-Mix</td><td align="left">3</td><td align="left"><span style="width: 80.287498px;"><svg height="12.2375" id="M10" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">5</tspan>
</text>
</g>
</g>
</svg></span></td><td align="left"><span style="width: 72.474998px;"><svg height="12.2375" id="M11" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">5</tspan>
</text>
</g>
</g>
</svg></span></td><td align="left"><span style="width: 72.474998px;"><svg height="12.175" id="M12" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.175" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">0</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr><td align="left">pSilencer3.1-neo-Y</td><td align="left">3</td><td align="left"><span style="width: 80.287498px;"><svg height="12.175" id="M13" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.175" width="80.287498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">8</tspan>
</text>
</g>
</g>
</svg></span></td><td align="left"><span style="width: 80.287498px;"><svg height="12.2375" id="M14" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">1</tspan>
</text>
</g>
</g>
</svg></span></td><td align="left"><span style="width: 72.474998px;"><svg height="12.2375" id="M15" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">5</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr><td align="left">Control</td><td align="left">3</td><td align="left"><span style="width: 80.287498px;"><svg height="12.2375" id="M16" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">8</tspan>
</text>
</g>
</g>
</svg></span></td><td align="left"><span style="width: 80.287498px;"><svg height="12.2375" id="M17" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">2</tspan>
</text>
</g>
</g>
</svg></span></td><td align="left"><span style="width: 72.474998px;"><svg height="12.2375" id="M18" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">2</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Cell cycle distribution showing the percentage of cells in G0/G1, S and G2/M phase according to DNA content.

International Scholarly Research Notices

tab1

Table 1

Table 1: Downregulation of the Adenosine A2b Receptor by RNA Interference Inhibits Hepatocellular Carcinoma Cell Growth 