Research Article
Development and Validation of Stability-Indicating HPTLC Determination of Tamsulosin in Bulk and Pharmaceutical Dosage Form
Table 5
Forced degradation of tamsulosin hydrochloride.
| | Serial number | Sample exposure condition | Number of degradation products ( value) | Tamsulosin hydrochloride remained (ng/1200 ng) (±S.D, ) | S.E. | Recovery (%) |
| | 1 | 2 N HCl “8 h” at room temp. reflux for “1 h” | 1 (0.29) | 1055.8 (7.90) | 1.810 | 87.99 | | 2 | 2 N NaOH “8 h” room temp. reflux for “1 h” | 1 (0.26) | 983.76 (5.01) | 2.092 | 81.98 | | 3 | 30% H2O2 “16 h” | 1 (0.34) | 1020.66 (14.00) | 2.034 | 85.06 | | 4 | Heat for “2 h” at 60°C | 1 (0.31) | 1028.72 (10.10) | 2.244 | 85.73 | | 5 | Photo degradation kept for “24 h” | 1 (0.28) | 1069.81 (16.81) | 0.900 | 89.15 |
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