Journal of Signal Transduction

Review Article

Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

Table 2

Amino acid identities (top right) and similarities (bottom left) of the SOCS2 molecules from fish, birds, amphibians, and mammals. The accession numbers of the protein sequences are given in Figure 3.


	aa	1	2	3	4	5	6	7	8	9	10	11	12	13

(1) Trout-a	201		41.3	24.1	79.1	79.1	74.1	73.6	74.1	51.2	51.2	51.2	47.3	55.8
(2) Trout-b	218	59.2		38.5	40.8	41.7	42.5	41.6	42	40.8	40.5	39.9	38.5	41.3
(3) Trout-bRel	110	36.3	39.9		23.9	24.4	26.2	25.1	23.9	25.8	25.3	24.7	24.2	25.9
(4) gCarp	197	89.6	60.6	35.5		95.4	75.3	73.1	71.6	57.9	57.9	57.9	49.5	54.1
(5) Zebrafish	197	89.6	60.1	35.5	98.5		75.1	72.5	71.1	57.9	56.4	57.9	50.5	53.9
(6) Stickleback	195	82.1	58.7	36.4	86.3	85.3		75.1	75.1	53.5	55.7	53.7	46.5	57.4
(7) Tetraodon	201	81.6	58.7	37.3	85.6	86.6	82.6		88.1	52.4	51.4	52.4	46.1	52.4
(8) Fugu	201	80.6	61	35.3	83.1	83.6	81.6	92		51.2	51.2	50.7	45.6	53.8
(9) Human	198	66.7	56.9	34.8	72.2	71.7	70.7	69.7	68.2		94.4	93.9	61.7	62.9
(10) Cow	198	69.2	57.8	35.4	72.7	71.7	72.2	70.6	68.2	96		92.9	61.9	62.4
(11) Mouse	198	68.2	57.3	34.3	72.7	72.2	70.2	68.7	66.2	95.5	94.4		61.6	61.4
(12) Chicken	207	63.3	56	32.9	64.7	64.3	63.3	62.8	63.8	75.4	76.3	74.9		60.4
(13) Frog	201	74.6	61.5	34.3	72.1	72.1	72.6	70.6	71.6	80.1	79.1	78.6	74.9