Review Article
Parasite Mitogen-Activated Protein Kinases as Drug Discovery Targets to Treat Human Protozoan Pathogens
Table 1
Non-Trypanosomatid mitogen-activated protein kinases discussed in this review.
| | Organism | MAPK | Accession no. | Phosphorylation lip | Classification | Function | References |
| | Caenorhabditis elegans | p38 | AAB00664 | TGY | Typical | Stress-response | [36] | | Drosophila melanogaster | p38α | AF035547 | TGY | Typical | Stress-response | [35] | | Entamoeba histolytica | EhMAPK | AY460178 | TDY | Typical | ? | | | Giardia intestinalis | ERK1 | AY149274 | TEY | Typical | Encystation | [49] | | ERK2 | AY149275 | TDY | Typical | Encystation | [49] | | Homo sapiens | p38α | Q16539 | TGY | Typical | Stress-response | [21, 34] | | Plasmodium falciparum | Pfmap-1 | Q94656 | TDY | Typical | ? | | | Pfmap-2 | Q25917 | TSH | Atypical | Essential for differentiation | [48] | | Saccharomyces cerevisiae | Hog1 | AAA34680 | TGY | Typical | Stress-response | [6] | | Toxoplasma gondii | TgMAPK1
(BARKY) | AY684849 | TDY | Typical | Proliferation†, differentiation†, virulence† | | | TgMAPK2 | DQ115400 | TDY | Typical | ? | | | TgMAPK3 | XP_0022369585 | TGH | Atypical | ? | |
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†Brumlik et al., submitted.
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