Activity of Cuban Plants Extracts against Leishmania amazonensis
Table 2
Antileishmanial activity and cytotoxicity of Cuban plants extracts.
Plants species
I ± SDb (g/mL)
C ± SD (g/mL)
SId
A. sativum
153.2 ± 2.1
—
—
A. barbadensis
77.5 ± 0.9
150.3 ± 3.4
2
A. sessilis
>200
—
—
A. glabra
37.8 ± 0.1
—
—
A. mexicana
>200
—
—
A. absinthium
129.0 ± 1.5
—
—
A. vulgaris
55.0 ± 3.2
107.7 ± 5.1
2
A. indica
>200
—
—
B. vulgaris (leaves)
60.5 ± 7.3
276.5 ± 1.2
5
B. vulgaris (root)
191.6 ± 1.1
—
—
B. pilosa
73.7 ± 0.1
222.8 ± 1.1
3
B. simaruba
163.3 ± 1.8
C. cajan
51.7 ± 0.7
132.5 ± 5.7
3
C. grandis
>200
—
—
C. peltata
>200
—
—
C. ambrosioides
>200
—
—
C. sicyoides
>200
—
—
C. limetta
73.6 ± 1.3
210.6 ± 3.9
3
C. maxima
62.2 ± 0.1
161.7 ± 0.9
3
C. sempervirens
>200
—
—
C. longa
>200
—
—
C. citrate
>200
—
—
H. crepitans
16.4 ± 2.1
390.5 ± 8.6
24
I. suffruticosa
75.8 ± 4.5
158.5 ± 6.2
2
K. villosum
>200
—
—
L. virginicum
109.7 ± 1.8
—
—
L. cylindrica
127.9 ± 1.0
—
—
M. indica
51.2 ± 0.1
442.4 ± 2.9
9
M. leucadendron
57.2 ± 2.9
199.2 ± 4.7
3
M. azedarach
168.6 ± 1.9
—
—
M. charantia
59.8 ± 0.4
26.7 ± 0.3
0
O. sanctum
96.9 ± 0.1
216.9 ± 4.8
2
P. hysterophorus (leaves)
54.7 ± 1.2
89.2 ± 1.5
0
P. hysterophorus (root)
46.9 ± 1.7
140.2 ± 0.2
3
P. alliaceae
151.5 ± 4.1
—
—
P. pentandra
140.8 ± 1.4
—
—
P. oleracea
63.9 ± 2.6
125.9 ± 1.9
2
P. granatum
39.4 ± 8.8
129.0 ± 4.6
3
R. spathacea
71.4 ± 1.4
244.6 ± 1.6
3
R. regia
>200
—
—
S. glauca
47.5 ± 0
228.7 ± 8.0
5
S. jamaicensis
111.8 ± 1.2
—
—
T. citrifolia
>200
—
—
T. indica
>200
—
—
T. peruviana
>200
—
—
T. havanensis
>200
—
—
T. ulmifolia
>200
—
—
Z. speciosum
133.1 ± 0.8
—
—
Pentamidine
0.37 ± 0.01
11.7 ± 1.7
32
aIC50: concentration of drug that caused 50% of growth inhibition of promastigotes of L. amazonensis.
bSD: standard deviation.
cCC50: concentration of drug that caused 50% of mortality of peritoneal macrophage from BALB/c.
dSI: selectivity index. Bold data indicate the extract selected.