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Research Article

Activity of Cuban Plants Extracts against Leishmania amazonensis

Table 2

Antileishmanial activity and cytotoxicity of Cuban plants extracts.
Plants speciesI C 5 0 a   ± SDb ( 𝜇 g/mL)C C 5 0 c   ± SD ( 𝜇 g/mL)SId
A. sativum153.2 ± 2.1——
A. barbadensis77.5 ± 0.9150.3 ± 3.42
A. sessilis>200——
A. glabra37.8 ± 0.1——
A. mexicana>200——
A. absinthium129.0 ± 1.5——
A. vulgaris55.0 ± 3.2107.7 ± 5.12
A. indica>200——
B. vulgaris (leaves)60.5 ± 7.3276.5 ± 1.25
B. vulgaris (root)191.6 ± 1.1——
B. pilosa73.7 ± 0.1222.8 ± 1.13
B. simaruba163.3 ± 1.8
C. cajan51.7 ± 0.7132.5 ± 5.73
C. grandis>200——
C. peltata>200——
C. ambrosioides>200——
C. sicyoides>200——
C. limetta73.6 ± 1.3210.6 ± 3.93
C. maxima62.2 ± 0.1161.7 ± 0.93
C. sempervirens>200——
C. longa>200——
C. citrate>200——
H. crepitans16.4 ± 2.1390.5 ± 8.624
I. suffruticosa75.8 ± 4.5158.5 ± 6.22
K. villosum>200——
L. virginicum109.7 ± 1.8——
L. cylindrica127.9 ± 1.0——
M. indica51.2 ± 0.1442.4 ± 2.99
M. leucadendron57.2 ± 2.9199.2 ± 4.73
M. azedarach168.6 ± 1.9——
M. charantia59.8 ± 0.426.7 ± 0.30
O. sanctum96.9 ± 0.1216.9 ± 4.82
P. hysterophorus (leaves)54.7 ± 1.289.2 ± 1.50
P. hysterophorus (root)46.9 ± 1.7140.2 ± 0.23
P. alliaceae151.5 ± 4.1——
P. pentandra140.8 ± 1.4——
P. oleracea63.9 ± 2.6125.9 ± 1.92
P. granatum39.4 ± 8.8129.0 ± 4.63
R. spathacea71.4 ± 1.4244.6 ± 1.63
R. regia >200——
S. glauca47.5 ± 0228.7 ± 8.05
S. jamaicensis111.8 ± 1.2——
T. citrifolia>200——
T. indica>200——
T. peruviana>200——
T. havanensis>200——
T. ulmifolia>200——
Z. speciosum133.1 ± 0.8——
Pentamidine0.37 ± 0.0111.7 ± 1.732
aIC50: concentration of drug that caused 50% of growth inhibition of promastigotes of L. amazonensis.
bSD: standard deviation.
cCC50: concentration of drug that caused 50% of mortality of peritoneal macrophage from BALB/c.
dSI: selectivity index.
Bold data indicate the extract selected.